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Journal article

Synthesis and anticancer activities of 6-amino amonafide derivatives.

Abstract:

Amonafide is a DNA intercalator and topoisomerase II inhibitor in clinical development for the treatment of neoplastic diseases. Amonafide contains a free arylamine, which causes it to be metabolized in humans by N-acetyl transferase-2 (NAT2) into a toxic form. To eliminate the NAT2 acetylation of amonafide while retaining the anticancer properties, we have synthesized nine derivatives that are structurally similar to amonafide that should not be acetylated. Eight derivatives have arylamines ...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author
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Journal:
Anti-cancer drugs
Volume:
19
Issue:
1
Pages:
23-36
Publication date:
2008-01-01
DOI:
EISSN:
1473-5741
ISSN:
0959-4973
Source identifiers:
289142

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