Journal article icon

Journal article

Aberrant trafficking of transmembrane proteins in human disease.

Abstract:
Transmembrane domain (TMD) proteins comprise a major group of proteins that perform a wide range of functions and act to translate extracellular signals to intracellular responses. They include G-protein coupled receptors (GPCRs), growth factor receptors, ion channels, transporters and metabolic enzymes. In this review, we focus on the current understanding of trafficking of mutant membrane proteins in human disease and speculate on therapeutic strategies.
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1016/j.tcb.2003.10.008

Authors


Cobbold, C More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, WTC Human Genetics
Sivaprasadarao, A More by this author
Ponnambalam, S More by this author
Journal:
Trends in cell biology
Volume:
13
Issue:
12
Pages:
639-647
Publication date:
2003-12-05
DOI:
EISSN:
1879-3088
ISSN:
0962-8924
URN:
uuid:b720dec0-9e58-446d-be2a-b0a5d7b7e5a2
Source identifiers:
32541
Local pid:
pubs:32541

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP