- Abstract:
- Transmembrane domain (TMD) proteins comprise a major group of proteins that perform a wide range of functions and act to translate extracellular signals to intracellular responses. They include G-protein coupled receptors (GPCRs), growth factor receptors, ion channels, transporters and metabolic enzymes. In this review, we focus on the current understanding of trafficking of mutant membrane proteins in human disease and speculate on therapeutic strategies.
- Publication status:
- Published
- Publisher copy:
- 10.1016/j.tcb.2003.10.008
-
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- Journal:
- Trends in cell biology
- Volume:
- 13
- Issue:
- 12
- Pages:
- 639-647
- Publication date:
- 2003-12-05
- DOI:
- EISSN:
-
1879-3088
- ISSN:
-
0962-8924
- URN:
-
uuid:b720dec0-9e58-446d-be2a-b0a5d7b7e5a2
- Source identifiers:
-
32541
- Local pid:
- pubs:32541
- Copyright date:
- 2003
Journal article
Aberrant trafficking of transmembrane proteins in human disease.
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