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Journal article

Aberrant trafficking of transmembrane proteins in human disease.

Abstract:
Transmembrane domain (TMD) proteins comprise a major group of proteins that perform a wide range of functions and act to translate extracellular signals to intracellular responses. They include G-protein coupled receptors (GPCRs), growth factor receptors, ion channels, transporters and metabolic enzymes. In this review, we focus on the current understanding of trafficking of mutant membrane proteins in human disease and speculate on therapeutic strategies.
Publication status:
Published

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Publisher copy:
10.1016/j.tcb.2003.10.008

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
Journal:
Trends in cell biology
Volume:
13
Issue:
12
Pages:
639-647
Publication date:
2003-12-01
DOI:
EISSN:
1879-3088
ISSN:
0962-8924
Source identifiers:
32541
Language:
English
Keywords:
Pubs id:
pubs:32541
UUID:
uuid:b720dec0-9e58-446d-be2a-b0a5d7b7e5a2
Local pid:
pubs:32541
Deposit date:
2012-12-19

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