Journal article

Harnessing the beneficial heterologous effects of vaccination.

Abstract:: Clinical evidence strongly suggests that certain live vaccines, in particular BCG and measles vaccines, can reduce all-cause mortality, likely via protection against non-targeted pathogens in addition to the targeted pathogen. The underlying mechanisms are currently unknown. We discuss how heterologous lymphocyte activation and innate immune memory could promote protection beyond the intended target and consider how vaccinologists could leverage heterologous immunity to improve outcomes in vulnerable populations, in particular the very young and the elderly.

Publication status:: Published

Peer review status:: Peer reviewed

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APA Style

Goodridge, H., Ahmed, S., Curtis, N., Kollmann, T., Levy, O., Netea, M., Pollard, A., van Crevel, R., & Wilson, C. (2016). Harnessing the beneficial heterologous effects of vaccination. Nature Reviews Immunology, 16, 392–400.

MLA Style

Goodridge, H, et al. “Harnessing the Beneficial Heterologous Effects of Vaccination.” Nature Reviews Immunology, vol. 16, 2016, pp. 392–400.

Chicago Style

Goodridge, H, S Ahmed, N Curtis, et al. 2016. “Harnessing the Beneficial Heterologous Effects of Vaccination.” Nature Reviews Immunology 16: 392–400.
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Files:: Pollard et al, Harnessing the beneficial heterologous effects ...

(Preview, Accepted manuscript, pdf, 199.1KB, Terms of use)

Publisher copy:: 10.1038/nri.2016.43

Authors

+ Goodridge, H More by this author

Role:: Author

+ Ahmed, S More by this author

Role:: Author

+ Curtis, N More by this author

Role:: Author

+ Kollmann, T More by this author

Role:: Author

+ Levy, O More by this author

Role:: Author

More authors...

+ Canadian Institute of Health Research More from this funder

Grant:: 300819

+ European Research Council More from this funder

Grant:: 310372

+ National Institutes of Health More from this funder

Grant:: RO1 5R01AI100135-03

+ National Institute of Health Research More from this funder

Funding agency for:: Pollard, A

+ British Columbia Children’s Hospital Foundation More from this funder

More funders...

Publisher:: Nature Publishing Group
Journal:: Nature Reviews Immunology More from this journal
Volume:: 16
Pages:: 392-400
Publication date:: 2016-05-01
DOI:: 10.1038/nri.2016.43
EISSN:: 1474-1741
ISSN:: 1474-1733

Language:: English
Pubs id:: pubs:622357
UUID:: uuid:b717761a-7449-4264-9bb0-4160ce4ea0c9
Local pid:: pubs:622357
Source identifiers:: 622357
Deposit date:: 2016-05-15
ARK identifier:: ark:/29072/ora_b717761a744942649bb04160ce4ea0c9

Terms of use

Copyright holder:: Macmillan Publishers Limited
Copyright date:: 2016
Notes:: © 2016 Macmillan Publishers Limited. All rights reserved

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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