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A synthetic holliday junction is sandwiched between two tetrameric Mycobacterium leprae RuvA structures in solution: new insights from neutron scattering contrast variation and modelling.

Abstract:

The interaction between homologous DNA molecules in recombination and DNA repair leads to the formation of crossover intermediates known as Holliday junctions. Their enzymatic processing by the RuvABC system in bacteria involves the formation of a complex between RuvA and the Holliday junction. To study the solution structure of this complex, contrast variation by neutron scattering was applied to Mycobacterium leprae RuvA (MleRuvA), a synthetic analogue of a Holliday junction with 16 base-pa...

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Publication status:
Published

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Publisher copy:
10.1006/jmbi.1998.2177

Authors


Chamberlain, D More by this author
Arenas-Licea, J More by this author
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Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry
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Journal:
Journal of molecular biology
Volume:
284
Issue:
2
Pages:
385-400
Publication date:
1998-11-05
DOI:
EISSN:
1089-8638
ISSN:
0022-2836
URN:
uuid:b716f6e6-e59a-4552-bdf1-2a1bc07088f4
Source identifiers:
400261
Local pid:
pubs:400261

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