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A prospective, randomized, placebo-controlled, double-blind, multicenter study of the effects of irbesartan on aortic dilatation in Marfan syndrome (AIMS trial): study protocol.

Abstract:

BACKGROUND: Cardiovascular complications are the leading cause of mortality and morbidity in Marfan syndrome (MFS), a dominantly inherited disorder caused by mutations in the gene that encodes fibrillin-1. There are approximately 18,000 patients in the UK with MFS. Current treatment includes careful follow-up, beta blockers, and prophylactic surgical intervention; however, there is no known treatment which effectively prevents the rate of aortic dilatation in MFS. Preclinical, neonatal, and p...

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Publication status:
Published

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Publisher copy:
10.1186/1745-6215-14-408

Authors


Mullen, MJ More by this author
Flather, MD More by this author
Newman, WG More by this author
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Journal:
Trials
Volume:
14
Issue:
1
Pages:
408
Publication date:
2013
DOI:
EISSN:
1745-6215
ISSN:
1745-6215
URN:
uuid:b7072b70-2237-4904-85cb-55b3646a0f30
Source identifiers:
441885
Local pid:
pubs:441885

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