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Orexin neurons as conditional glucosensors: Paradoxical regulation of sugar sensing by intracellular fuels

Abstract:

Central orexin/hypocretin neurons promote wakefulness, feeding and reward-seeking, and control blood glucose levels by regulating sympathetic outflow to the periphery. Glucose itself directly suppresses the electrical activity and cytosolic calcium levels of orexin cells. Recentin vitrostudies suggested that glucose inhibition of orexin cells may be mechanistically unusual, because it persists under conditions where glucose metabolism is unlikely. To investigate this further, and to clarify w...

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Journal:
Journal of Physiology
Volume:
589
Issue:
23
Pages:
5701-5708
Publication date:
2011-12-05
DOI:
EISSN:
1469-7793
ISSN:
0022-3751
URN:
uuid:b6eb2299-4868-4bc8-8a4a-cbf68922e81a
Source identifiers:
314914
Local pid:
pubs:314914
Language:
English

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