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Defective nuclear localization of Hsp70 is associated with dyserythropoiesis and GATA-1 cleavage in myelodysplastic syndromes.

Abstract:

Normal human erythroid cell maturation requests the transcription factor GATA-1 and a transient activation of caspase-3, with GATA-1 being protected from caspase-3-mediated cleavage by interaction with the chaperone heat shock protein 70 (Hsp70) in the nucleus. Erythroid cell dysplasia observed in early myelodysplastic syndromes (MDS) involves impairment of differentiation and excess of apoptosis with a burst of caspase activation. Analysis of gene expression in MDS erythroblasts obtained by ...

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Publication status:
Published

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Authors


Vandekerckhove, J More by this author
de Thonel, A More by this author
Pierre-Eugène, C More by this author
Sternberg, A More by this author
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Journal:
Blood
Volume:
119
Issue:
6
Pages:
1532-1542
Publication date:
2012-02-05
DOI:
EISSN:
1528-0020
ISSN:
0006-4971
URN:
uuid:b6d757f2-18c5-4498-94bc-625d0372a29f
Source identifiers:
316623
Local pid:
pubs:316623

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