- Abstract:
-
In a genome-wide association study to identify loci associated with colorectal cancer (CRC) risk, we genotyped 555,510 SNPs in 1,012 early-onset Scottish CRC cases and 1,012 controls (phase 1). In phase 2, we genotyped the 15,008 highest-ranked SNPs in 2,057 Scottish cases and 2,111 controls. We then genotyped the five highest-ranked SNPs from the joint phase 1 and 2 analysis in 14,500 cases and 13,294 controls from seven populations, and identified a previously unreported association, rs3802...
Expand abstract - Publisher copy:
- 10.1038/ng.133
-
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- Journal:
- Nature genetics
- Volume:
- 40
- Issue:
- 5
- Pages:
- 631-637
- Publication date:
- 2008-05-05
- DOI:
- EISSN:
-
1546-1718
- ISSN:
-
1061-4036
- URN:
-
uuid:b6d398b0-36b7-4ac3-82e4-caa88825d191
- Source identifiers:
-
72264
- Local pid:
- pubs:72264
- Copyright date:
- 2008
Journal article
Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21.
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