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Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21.

Abstract:

In a genome-wide association study to identify loci associated with colorectal cancer (CRC) risk, we genotyped 555,510 SNPs in 1,012 early-onset Scottish CRC cases and 1,012 controls (phase 1). In phase 2, we genotyped the 15,008 highest-ranked SNPs in 2,057 Scottish cases and 2,111 controls. We then genotyped the five highest-ranked SNPs from the joint phase 1 and 2 analysis in 14,500 cases and 13,294 controls from seven populations, and identified a previously unreported association, rs3802...

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Publisher copy:
10.1038/ng.133

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Journal:
Nature genetics
Volume:
40
Issue:
5
Pages:
631-637
Publication date:
2008-05-05
DOI:
EISSN:
1546-1718
ISSN:
1061-4036
URN:
uuid:b6d398b0-36b7-4ac3-82e4-caa88825d191
Source identifiers:
72264
Local pid:
pubs:72264

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