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Hypoxia--a key regulator of angiogenesis and inflammation in rheumatoid arthritis.

Abstract:

The importance of inflammation in rheumatoid arthritis (RA) is well understood. This knowledge has resulted in the development of anti-inflammatory therapies--either broadly acting (such as steroids) or more specific approaches (such as antibodies against TNF)--with biologic therapies (including TNF inhibitors) revolutionizing the treatment of RA. However, what is less well appreciated in RA are the links between inflammation, blood-vessel formation (angiogenesis) and cellular responses to ch...

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Publication status:
Published

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Publisher copy:
10.1038/nrrheum.2011.205

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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Role:
Author
Journal:
Nature reviews. Rheumatology
Volume:
8
Issue:
3
Pages:
153-162
Publication date:
2012-03-05
DOI:
EISSN:
1759-4804
ISSN:
1759-4790
URN:
uuid:b6c8e801-435e-4bfd-bce8-09232881fef3
Source identifiers:
321049
Local pid:
pubs:321049

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