ENPP1 processes protein ADP-ribosylation in vitro.
ADP-ribosylation is a conserved post-translational protein modification that plays a role in all major cellular processes, particularly DNA repair, transcription, translation, stress response and cell death. Hence, dysregulation of ADP-ribosylation is linked to the physiopathology of several human diseases including cancers, diabetes and neurodegenerative disorders. Protein ADP-ribosylation can be reversed by the macrodomain-containing proteins PARG, TARG1, MacroD1 and MacroD2, which hydrolys...Expand abstract
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- Peer review status:
- Peer reviewed
- Copyright holder:
- Palazzo et al
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- © 2016 The Authors. The FEBS Journal published by John Wiley and Sons Ltd on behalf of Federation of European Biochemical Societies. This is an open access article under the terms of the Creative Commons Attribution License.
- CC Attribution (CC BY)
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