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Journal article

ENPP1 processes protein ADP-ribosylation in vitro.

Abstract:

ADP-ribosylation is a conserved post-translational protein modification that plays a role in all major cellular processes, particularly DNA repair, transcription, translation, stress response and cell death. Hence, dysregulation of ADP-ribosylation is linked to the physiopathology of several human diseases including cancers, diabetes and neurodegenerative disorders. Protein ADP-ribosylation can be reversed by the macrodomain-containing proteins PARG, TARG1, MacroD1 and MacroD2, which hydrolys...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1111/febs.13811

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
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Publisher:
Wiley Publisher's website
Journal:
FEBS Journal Journal website
Volume:
283
Issue:
18
Pages:
3371-3388
Publication date:
2016-07-12
Acceptance date:
2016-07-11
DOI:
ISSN:
1742-464X and 1742-4658
Pmid:
27406238
Language:
English
Keywords:
Pubs id:
pubs:636252
UUID:
uuid:b6bce3ec-2d4c-40e7-9325-a3c008562c40
Local pid:
pubs:636252
Deposit date:
2016-09-22

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