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Abdominal aortic aneurysm is associated with a variant in low-density lipoprotein receptor-related protein 1.

Abstract:

Abdominal aortic aneurysm (AAA) is a common cause of morbidity and mortality and has a significant heritability. We carried out a genome-wide association discovery study of 1866 patients with AAA and 5435 controls and replication of promising signals (lead SNP with a p value < 1 × 10(-5)) in 2871 additional cases and 32,687 controls and performed further follow-up in 1491 AAA and 11,060 controls. In the discovery study, nine loci demonstrated association with AAA (p < 1 × 10(-5)). In th...

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Publisher copy:
10.1016/j.ajhg.2011.10.002

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Journal:
American journal of human genetics
Volume:
89
Issue:
5
Pages:
619-627
Publication date:
2011-11-01
DOI:
EISSN:
1537-6605
ISSN:
0002-9297
Source identifiers:
415831

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