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T cell receptor signaling precedes immunological synapse formation.

Abstract:

The area of contact between a T cell and an antigen-presenting cell (APC) is known as the immunological synapse. Although its exact function is unknown, one model suggests that it allows for T cell receptor (TCR) clustering and for sustained signaling in T cells for many hours. Here we demonstrate that TCR-mediated tyrosine kinase signaling in naïve T cells occurred primarily at the periphery of the synapse and was largely abated before mature immunological synapses had formed. These data sug...

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Publisher copy:
10.1126/science.1067710

Authors


Holdorf, AD More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
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Journal:
Science (New York, N.Y.)
Volume:
295
Issue:
5559
Pages:
1539-1542
Publication date:
2002-02-05
DOI:
EISSN:
1095-9203
ISSN:
0036-8075
URN:
uuid:b66b37d2-8c8e-4980-9613-ddfa9ff87937
Source identifiers:
482656
Local pid:
pubs:482656

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