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Adult thymic medullary epithelium is maintained and regenerated by linage-restricted cells rather than bipotent progenitors

Abstract:

Medullary thymic epithelial cells (mTECs) play an essential role in establishing self-tolerance in T cells. mTECs originate from bipotent TEC progenitors that generate both mTECs and cortical TECs (cTECs), although mTEC-restricted progenitors also have been reported. Here, we report in vivo fate-mapping analysis of cells that transcribe β5t, a cTEC trait expressed in bipotent progenitors, during a given period in mice. We show that, in adult mice, most mTECs are derived from progenitors that ...

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Publication status:
In Press
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.celrep.2015.10.012

Authors


Izumi Ohigashi More by this author
Saulius Zuklys More by this author
Mie Sakata More by this author
Carlos E. Mayer More by this author
Yoko Hamazaki More by this author
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Project
Publisher:
Cell Press Publisher's website
Journal:
Cell Reports
DOI:
ISSN:
2211-1247

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