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Adult thymic medullary epithelium is maintained and regenerated by linage-restricted cells rather than bipotent progenitors

Abstract:

Medullary thymic epithelial cells (mTECs) play an essential role in establishing self-tolerance in T cells. mTECs originate from bipotent TEC progenitors that generate both mTECs and cortical TECs (cTECs), although mTEC-restricted progenitors also have been reported. Here, we report in vivo fate-mapping analysis of cells that transcribe β5t, a cTEC trait expressed in bipotent progenitors, during a given period in mice. We show that, in adult mice, most mTECs are derived from progenitors that ...

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Publication status:
In Press
Peer review status:
Peer reviewed

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Publisher:
Cell Press Publisher's website
Journal:
Cell Reports
DOI:
ISSN:
2211-1247

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