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Genome-wide associations for birth weight and correlations with adult disease

Abstract:

Birth weight (BW) is influenced by both foetal and maternal factors and in observational studies is reproducibly associated with future risk of adult metabolic diseases including type 2 diabetes (T2D) and cardiovascular disease. These lifecourse associations have often been attributed to the impact of an adverse early life environment. We performed a multi-ancestry genome-wide association study (GWAS) meta-analysis of BW in 153,781 individuals, identifying 60 loci where foetal genotype was...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/nature19806

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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
OCDEM
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
OCDEM
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
OCDEM
Role:
Author
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Publisher:
Nature Publishing Group Publisher's website
Journal:
Nature Journal website
Volume:
538
Pages:
248–252
Publication date:
2016-09-01
Acceptance date:
2016-09-02
DOI:
Source identifiers:
638171
Pubs id:
pubs:638171
UUID:
uuid:b66044a1-c565-454d-892b-8edda840017f
Local pid:
pubs:638171
Deposit date:
2016-08-10

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