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Cutting edge: Synapse propensity of human memory CD8 T cells confers competitive advantage over naive counterparts

Abstract:

Memory T cells are endowed with multiple functional features that enable them to be more protective than naive T cells against infectious threats. It is not known if memory cells have a higher synapse propensity (SP; i.e., increased probability to form immature immunological synapses that then provide an entry into different modes of durable interaction with APCs). In this study, we show that only human memory CD8 T cells have remarkably high SP compared with naive counterparts. Such a dichot...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.4049/jimmunol.1801687

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDORMS
Subgroup:
KIR
Oxford college:
St Peters College
Role:
Author
ORCID:
0000-0001-5668-9124
More by this author
Role:
Author
ORCID:
0000-0002-6689-9448
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDORMS
Subgroup:
KIR
Role:
Author
ORCID:
0000-0001-5033-8171
More by this author
Role:
Author
ORCID:
0000-0002-9619-5572
More by this author
Role:
Author
ORCID:
0000-0002-0218-4240
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Publisher:
American Association of Immunologists Publisher's website
Journal:
Journal of Immunology Journal website
Volume:
203
Issue:
1
Pages:
Article: ji1801687
Publication date:
2019-06-14
Acceptance date:
2019-05-28
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
Pubs id:
pubs:1019804
URN:
uri:b65bc210-ad05-4dd2-bab9-40d019430c8e
UUID:
uuid:b65bc210-ad05-4dd2-bab9-40d019430c8e
Local pid:
pubs:1019804
Language:
English

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