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Journal article

Loss of the tight junction proteins occludin and zonula occludens-1 from cerebral vascular endothelium during neutrophil-induced blood-brain barrier breakdown in vivo.

Abstract:

The tight junctions found between cerebral vascular endothelial cells form the basis of the blood-brain barrier. Breakdown of the blood-brain barrier is a feature of a variety of CNS pathologies that are characterized by extensive leucocyte recruitment, such as multiple sclerosis and stroke. The molecular mechanisms associated with opening of the blood-brain barrier and leucocyte recruitment in vivo are currently poorly understood. We have used an in vivo rat model to investigate the molecula...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
Pharmacology
Role:
Author
Journal:
Neuroscience More from this journal
Volume:
86
Issue:
4
Pages:
1245-1257
Publication date:
1998-10-01
DOI:
EISSN:
1873-7544
ISSN:
0306-4522
Language:
English
Keywords:
Pubs id:
pubs:383089
UUID:
uuid:b6536482-864d-4361-a67e-d8046778a55f
Local pid:
pubs:383089
Source identifiers:
383089
Deposit date:
2013-11-16

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