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Cannabis use and risk of schizophrenia: a Mendelian randomization study.

Abstract:

Cannabis use is observationally associated with an increased risk of schizophrenia, but whether the relationship is causal is not known. Using a genetic approach, we took 10 independent genetic variants previously identified to associate with cannabis use in 32 330 individuals to determine the nature of the association between cannabis use and risk of schizophrenia. Genetic variants were employed as instruments to recapitulate a randomized controlled trial involving two groups (cannabis users...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1038/mp.2016.252

Authors


Vaucher, J More by this author
Keating, BJ More by this author
Lasserre, AM More by this author
More by this author
Department:
Oxford, MSD, RDM, RDM OCDEM
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Funding agency for:
Holmes, M
Wellcome Trust More from this funder
Medical Research Council More from this funder
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Publisher:
Nature Publishing Group Publisher's website
Journal:
Molecular Psychiatry Journal website
Publication date:
2017-01-05
Acceptance date:
2016-11-28
DOI:
EISSN:
1476-5578
ISSN:
1359-4184
Pubs id:
pubs:673349
URN:
uri:b6368ab8-7f1b-4907-9a81-e77f5056e338
UUID:
uuid:b6368ab8-7f1b-4907-9a81-e77f5056e338
Local pid:
pubs:673349
Language:
English
Keywords:

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