Journal article
Studies on the interaction of the histone demethylase KDM5B with tricarboxylic acid cycle intermediates
- Abstract:
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Methylation of lysine-4 of histone H3 (H3K4men) is an important regulatory factor in eukaryotic transcription. Removal of the transcriptionally activating H3K4 methylation is catalyzed by histone demethylases, including the Jumonji C (JmjC) KDM5 subfamily. The JmjC KDMs are Fe(II) and 2-oxoglutarate (2OG)-dependent oxygenases, some of which are associated with cancer. Altered levels of tricarboxylic acid (TCA) cycle intermediates and the associated metabolites D- and L-2-hydroxyglutarate (2HG...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 857.6KB)
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(Version of record, pdf, 1.1MB)
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- Publisher copy:
- 10.1016/j.jmb.2017.08.007
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Authors
Funding
Rosetrees Trust
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Wellcome Trust
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Bibliographic Details
- Publisher:
- Elsevier Publisher's website
- Journal:
- Journal of Molecular Biology Journal website
- Volume:
- 429
- Issue:
- 19
- Pages:
- 2895-2906
- Publication date:
- 2017-08-18
- Acceptance date:
- 2017-08-14
- DOI:
- EISSN:
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1089-8638
- ISSN:
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0022-2836
- Source identifiers:
-
723910
Item Description
- Keywords:
- Pubs id:
-
pubs:723910
- UUID:
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uuid:b5fb5adf-5181-4c9b-8d24-fafbc18d7c81
- Local pid:
- pubs:723910
- Deposit date:
- 2017-08-22
Terms of use
- Copyright holder:
- Tarhonskaya et al
- Copyright date:
- 2017
- Notes:
-
Copyright © 2017 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license
(http://creativecommons.org/licenses/by/4.0/).
- Licence:
- CC Attribution (CC BY)
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