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Exploiting trans ‐Sulfinylation for the Synthesis of Diverse N ‐Alkyl Sulfinamides via Decarboxylative Sulfinamidation

Abstract:
Combining simple amines with the bench‐stable sulfinylamine Tr‐NSO allows in situ preparation of reactive alkyl sulfinylamines, which when combined with alkyl radicals generated by photocatalytic decarboxylation, provides N‐alkyl sulfinamides. The reactions are broad in scope and tolerate a wide variety of functional groups on both the acid and amine components. The sulfinamide products are used to prepare a selection of challenging S(VI) products. The method provides a convenient way to use reactive and unstable alkyl sulfinylamines.
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1002/ange.202407970

Authors

More by this author
Institution:
University of Oxford
Division:
HUMS
Department:
Classics Faculty
Sub department:
Chemistry Research Laboratory
Role:
Author
More by this author
Institution:
University of Oxford
Division:
HUMS
Department:
Classics Faculty
Sub department:
Chemistry Research Laboratory
Role:
Author
More by this author
Institution:
University of Oxford
Division:
HUMS
Department:
Classics Faculty
Sub department:
Chemistry Research Laboratory
Role:
Author
ORCID:
0000-0002-0636-6471



Publisher:
Wiley
Journal:
Angewandte Chemie More from this journal
Article number:
e202407970
Publication date:
2024-08-22
DOI:
ISSN:
0044-8249, 1521-3757


Language:
English
Keywords:
Pubs id:
2016116
Local pid:
pubs:2016116
Source identifiers:
2206623
Deposit date:
2024-08-22
ARK identifier:
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