Journal article
MBL genotype and risk of invasive pneumococcal disease: a case-control study.
- Abstract:
-
BACKGROUND: Streptococcus pneumoniae is a major cause of morbidity and mortality in developed and developing countries. No common genetic determinants of susceptibility have been defined. Mannose-binding lectin (MBL) is a key mediator of innate host immunity that activates the complement pathway and directly opsonises some infectious pathogens. Mutations in three codons in the MBL gene have been identified, and individuals homozygous for a mutant genotype have very little or no serum MBL. We...
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- Publication status:
- Published
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- Publisher copy:
- 10.1016/s0140-6736(02)08516-1
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Authors
Bibliographic Details
- Journal:
- Lancet
- Volume:
- 359
- Issue:
- 9317
- Pages:
- 1569-1573
- Publication date:
- 2002-05-01
- DOI:
- EISSN:
-
1474-547X
- ISSN:
-
0140-6736
- Source identifiers:
-
22340
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:22340
- UUID:
-
uuid:b5f308d5-8530-49e5-9ee9-4217483ff6d8
- Local pid:
- pubs:22340
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 2002
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