- Abstract:
-
BACKGROUND: Streptococcus pneumoniae is a major cause of morbidity and mortality in developed and developing countries. No common genetic determinants of susceptibility have been defined. Mannose-binding lectin (MBL) is a key mediator of innate host immunity that activates the complement pathway and directly opsonises some infectious pathogens. Mutations in three codons in the MBL gene have been identified, and individuals homozygous for a mutant genotype have very little or no serum MBL. We...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1016/s0140-6736(02)08516-1
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- Journal:
- Lancet
- Volume:
- 359
- Issue:
- 9317
- Pages:
- 1569-1573
- Publication date:
- 2002-05-05
- DOI:
- EISSN:
-
1474-547X
- ISSN:
-
0140-6736
- URN:
-
uuid:b5f308d5-8530-49e5-9ee9-4217483ff6d8
- Source identifiers:
-
22340
- Local pid:
- pubs:22340
- Language:
- English
- Keywords:
- Copyright date:
- 2002
Journal article
MBL genotype and risk of invasive pneumococcal disease: a case-control study.
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