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MBL genotype and risk of invasive pneumococcal disease: a case-control study.

Abstract:

BACKGROUND: Streptococcus pneumoniae is a major cause of morbidity and mortality in developed and developing countries. No common genetic determinants of susceptibility have been defined. Mannose-binding lectin (MBL) is a key mediator of innate host immunity that activates the complement pathway and directly opsonises some infectious pathogens. Mutations in three codons in the MBL gene have been identified, and individuals homozygous for a mutant genotype have very little or no serum MBL. We...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Primary Care Health Sciences
Role:
Author
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Journal:
Lancet
Volume:
359
Issue:
9317
Pages:
1569-1573
Publication date:
2002-05-05
DOI:
EISSN:
1474-547X
ISSN:
0140-6736
URN:
uuid:b5f308d5-8530-49e5-9ee9-4217483ff6d8
Source identifiers:
22340
Local pid:
pubs:22340

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