BACKGROUND: Streptococcus pneumoniae is a major cause of morbidity and mortality in developed and developing countries. No common genetic determinants of susceptibility have been defined. Mannose-binding lectin (MBL) is a key mediator of innate host immunity that activates the complement pathway and directly opsonises some infectious pathogens. Mutations in three codons in the MBL gene have been identified, and individuals homozygous for a mutant genotype have very little or no serum MBL. We...Expand abstract
- Publication status:
- Publisher copy:
- Copyright date:
MBL genotype and risk of invasive pneumococcal disease: a case-control study.
Views and Downloads
If you are the owner of this record, you can report an update to it here: Report update to this record