Journal article
Integrating new memories into the hippocampal network activity space
- Abstract:
- By investigating the topology of neuronal co-activity, we found that mnemonic information spans multiple operational axes in the mouse hippocampus network. High-activity principal cells form the core of each memory along a first axis, segregating spatial contexts and novelty. Low-activity cells join co-activity motifs across behavioral events and enable their crosstalk along two other axes. This reveals an organizational principle for continuous integration and interaction of hippocampal memories.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Preview, Accepted manuscript, 5.0MB, Terms of use)
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- Publisher copy:
- 10.1038/s41593-021-00804-w
Authors
+ Biotechnology and Biological Sciences Research Council
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- Grant:
- BB/N00597X/1
- BB/N002547/1
- BB/S007741/1
- Publisher:
- Nature Research
- Journal:
- Nature Neuroscience More from this journal
- Volume:
- 24
- Issue:
- 3
- Pages:
- 326-330
- Publication date:
- 2021-02-18
- Acceptance date:
- 2021-01-19
- DOI:
- EISSN:
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1546-1726
- ISSN:
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1097-6256
- Language:
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English
- Keywords:
- Pubs id:
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1157710
- Local pid:
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pubs:1157710
- Deposit date:
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2021-01-21
Terms of use
- Copyright holder:
- Gava et al.
- Copyright date:
- 2021
- Rights statement:
- Copyright © 2021, The Author(s), under exclusive licence to Springer Nature America, Inc.
- Notes:
- This is the accepted manuscript version of the article. The final version is available online from Nature Research at https://doi.org/10.1038/s41593-021-00804-w
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