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Crystal structure of the acid-induced arginine decarboxylase from Escherichia coli: reversible decamer assembly controls enzyme activity.

Abstract:

The acid-induced arginine decarboxylase is part of an enzymatic system in Escherichia coli that contributes to making this organism acid resistant. The arginine decarboxylase is a vitamin B(6)-dependent enzyme that is active at acidic pH. It consumes a proton in the decarboxylation of arginine to agmatine, and by working in tandem with an arginine-agmatine antiporter, this enzymatic cycle protects the organism by preventing the accumulation of protons inside the cell. We have determined the s...

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Publication status:
Published

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Publisher copy:
10.1021/bi900075d

Authors


Andréll, J More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Structural Genomics Consortium
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Journal:
Biochemistry
Volume:
48
Issue:
18
Pages:
3915-3927
Publication date:
2009-05-05
DOI:
EISSN:
1520-4995
ISSN:
0006-2960
URN:
uuid:b5dd6241-aa35-4347-a00c-369c0c7c1bba
Source identifiers:
72768
Local pid:
pubs:72768

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