Genetic studies of disorders of calcium crystal deposition.

Journal article

In summary, although many factors are likely to be involved in regulating calcification and ossification processes, studies of the causation of articular chondrocalcinosis and disorders of spinal ossification, such as DISH and OPLL, implicate control over inorganic pyrophosphate levels as being one of the most important factors in their aetiopathogenesis. The findings of these studies may prove relevant to other rheumatic diseases in which ectopic ossification occurs, such as AS.

Authors: Timms, A; Zhang, Y; Russell, R; Brown, M

• Publication status: Published
• Journal: Rheumatology (Oxford, England)
• Volume: 41
• Issue: 7
• Pages: 725-729
• Publication date: 2002-07-01
• DOI: 10.1093/rheumatology/41.7.725
• EISSN: 1462-0332
• ISSN: 1462-0324
• Language: English
• Keywords: Chondrocalcinosis; Male; Aged; Humans; Crystallization; Aged, 80 and over; Middle Aged; Genetic Predisposition to Disease; Cartilage, Articular; Cartilage Diseases; Calcium Pyrophosphate; Female