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Treatment of advanced neuroendocrine tumours using combination chemotherapy with lomustine and 5-fluorouracil.

Abstract:

OBJECTIVE: Combination chemotherapy with the two agents streptozotocin (SZT), which is a nitrosurea, and 5-fluorouracil (5-FU), an alkylating agent, has a long-established role in the treatment of neuroendocrine tumours; however, it is often accompanied by considerable toxicity, and it has not been assessed in a comparative manner with other current chemotherapy regimens. In order to assess the therapeutic response and adverse effects using an alternative nitrosurea, lomustine (CCNU), which h...

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Publication status:
Published

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Journal:
Clinical endocrinology
Volume:
57
Issue:
2
Pages:
169-183
Publication date:
2002-08-05
DOI:
EISSN:
1365-2265
ISSN:
0300-0664
URN:
uuid:b5bda9b1-3c19-49a2-b259-cbb66c072156
Source identifiers:
138347
Local pid:
pubs:138347

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