'Favourable' IL28B polymorphisms are associated with a marked increase in baseline viral load in hepatitis C virus subtype 3a infection and do not predict a sustained virological response after 24 weeks of therapy.

Journal article

IL28B host genetic make-up is known to play a critical role in the outcome of genotype 1 hepatitis C virus (HCV) infection in the context of both primary infection and therapy. However, the role of IL28B in subtype 3a infection remains unclear, and has not yet been assessed in the UK population where subtype 3a is dominant. In this study, we evaluated the role of the IL28B single-nucleotide polymorphism rs8099917 in 201 patients recruited from two well-defined cohorts (from Nottingham and Oxf...

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Authors: Bucci, C; von Delft, A; Christian, A; Flemming, V; Harrison, A

• Publication status: Published
• Journal: Journal of general virology
• Volume: 94
• Issue: Pt 6
• Pages: 1259-1265
• Publication date: 2013-06-01
• DOI: 10.1099/vir.0.051052-0
• EISSN: 1465-2099
• ISSN: 0022-1317
• Language: English
• Keywords: Humans; Young Adult; Ribavirin; Hepacivirus; Adult; Middle Aged; Aged; Interferons; Viral Load; Interleukins; Male; Polymorphism, Single Nucleotide; Prospective Studies; Cohort Studies; Antiviral Agents; Female; Genetic Predisposition to Disease; Great Britain; Genotype; Hepatitis C