Journal article
Childhood cancer incidence in British Indians and Whites in Leicester, 1996-2008
- Abstract:
- BACKGROUND: South Asians in England have an increased risk of childhood cancer but incidence by their individual ethnicities using self-assigned ethnicity is unknown. Our objective was to compare the incidence of childhood cancer in British Indians and Whites in Leicester, which has virtually complete, self-assigned, ethnicity data and the largest population of Indians in England. METHODS: We obtained data on all cancer registrations from 1996 to 2008 for Leicester with ethnicity obtained by linkage to the Hospital Episodes Statistics database. Age-standardised incidence rates were calculated for childhood cancers in Indians and Whites as well as rate ratios, adjusted for age. RESULTS: There were 33 cancers registered among Indian children and 39 among White children. The incidence rate for Indians was greater compared to Whites for all cancers combined (RR 1.82 (95% CI 1.14 to 2.89); p = 0.01), with some evidence of increased risk of leukaemia (RR 2.20 (0.95 to 5.07); p = 0.07), lymphoma (RR 3.96 (0.99 to 15.84); p = 0.04) and central nervous system tumours (RR 2.70 (1.00 to 7.26); p = 0.05). Rates were also higher in British Indian children compared to children in India. CONCLUSIONS: British Indian children in Leicester had an increased risk of developing cancer compared to White children, largely due to a higher incidence of central nervous system and haematological malignancies.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 139.2KB, Terms of use)
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- Publisher copy:
- 10.1371/journal.pone.0061881
Authors
- Publisher:
- Public Library of Science
- Journal:
- PLoS ONE More from this journal
- Volume:
- 8
- Issue:
- 4
- Pages:
- e61881
- Publication date:
- 2013-04-17
- Acceptance date:
- 2013-03-18
- DOI:
- EISSN:
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1932-6203
- Language:
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English
- Keywords:
- UUID:
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uuid:b56e700b-820a-439c-b817-fc83d2ab8288
- Local pid:
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pubs:401542
- Source identifiers:
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401542
- Deposit date:
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2013-11-17
Terms of use
- Copyright holder:
- Sayeed et al
- Copyright date:
- 2013
- Notes:
- © 2013 Sayeed et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
- Licence:
- CC Attribution (CC BY)
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