Journal article

P63 targeted deletion under the FOXN1 promoter disrupts pre-and post-natal thymus development, function and maintenance as well as induces severe hair loss

Abstract:: A clear healthy cornea is essential for visual acuity. As a self-renewing and regenerating tissue, the corneal epithelium has a stem cell pool, the limbus that acts as its proliferative reservoir. When limbal epithelial stem cells are destroyed or become dysfunctional, a pathological state known as limbal stem cell deficiency (LSCD) manifests. Damaged corneas have been successfully reconstructed by transplanting the cultured limbal epithelial stem cells. Limbal stem cell transplantation (LSCT...
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Publication status:: Published

Peer review status:: Peer reviewed

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APA Style

Stefanski, H. E., Xing, Y., Nicholls, J., Jonart, L., Goren, E., Taylor, P. A., Mills, A. A., Riddle, M., McGrath, J., Tolar, J., Hollander, G. A., & Blazar, B. R. (2022). P63 targeted deletion under the FOXN1 promoter disrupts pre-and post-natal thymus development, function and maintenance as well as induces severe hair loss. PLoS ONE, 17(1), e0261770–e0261770.

MLA Style

Stefanski, HE, et al. “P63 Targeted Deletion under the FOXN1 Promoter Disrupts Pre-and Post-Natal Thymus Development, Function and Maintenance as Well as Induces Severe Hair Loss.” PLoS ONE, vol. 17, no. 1, 2022, pp. e0261770–e0261770.

Chicago Style

Stefanski, HE, Y Xing, J Nicholls, et al. 2022. “P63 Targeted Deletion under the FOXN1 Promoter Disrupts Pre-and Post-Natal Thymus Development, Function and Maintenance as Well as Induces Severe Hair Loss.” PLoS ONE 17 (1): e0261770–e0261770.
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Files:: Stefanski_et_al_2022_P63_targeted_deletion.pdf

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Publisher copy:: 10.1371/journal.pone.0261770

Authors

+ Stefanski, HE More by this author

Role:: Author

+ Xing, Y More by this author

Role:: Author
ORCID:: 0000-0003-2150-1448

+ Nicholls, J More by this author

Role:: Author

+ Jonart, L More by this author

Role:: Author

+ Goren, E More by this author

Role:: Author

More authors...

+ Wellcome Trust More from this funder

Funder identifier:: 10.13039/100004440
Grant:: 066521

+ National Institutes of Health More from this funder

Funder identifier:: 10.13039/100000002
Grant:: P01 CA065493

Publisher:: Public Library of Science
Journal:: PLoS ONE More from this journal
Volume:: 17
Issue:: 1
Pages:: e0261770-e0261770
Publication date:: 2022-01-25
DOI:: 10.1371/journal.pone.0261770
EISSN:: 1932-6203
ISSN:: 1932-6203

Language:: English
Keywords:: Immune system

Stromal cell

Biology

T cell

Medicine

Morphogenesis

Cell biology

Thymic involution

Endocrinology

Immunology

Stem cell

Cancer research

Hair follicle

Embryonic stem cell

Internal medicine
Pubs id:: 1237620
Local pid:: pubs:1237620
Source identifiers:: W4206928578
Deposit date:: 2026-04-09
ARK identifier:: ark:/29072/ora_b56b52115c214fbebb00dae5c0b2ef8d

Terms of use

Copyright date:: 2022

Licence:: CC Attribution (CC BY)

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