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Ancistrocyclinones A and B, unprecedented pentacyclic N,C-coupled naphthylisoquinoline alkaloids, from the Chinese liana Ancistrocladus tectorius

Abstract:

Two unique pentacyclic N,C-coupled naphthylisoquinolines, the ancistrocyclinones A (5) and B (6), were discovered in the Chinese liana Ancistrocladus tectorius. Furthermore, six known, likewise N,C-coupled alkaloids, viz., ancistrocladinium A (7a) and its mono- and bisphenolic analogs 8a and 9a were isolated, along with their atropo-diastereomers 7b, 8b, and 9b. The stereostructures of 5 and 6 were determined by HRESIMS, 1D and 2D NMR, oxidative degradation, and ECD calculations. The pentacyc...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1039/c7ob03092d

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM; Target Discovery Institute
Hemberger, Y More by this author
Feineis, D More by this author
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Publisher:
Royal Society of Chemistry Publisher's website
Journal:
Organic and Biomolecular Chemistry Journal website
Volume:
16
Issue:
9
Pages:
1581-1590
Publication date:
2018-02-05
Acceptance date:
2018-02-05
DOI:
EISSN:
1477-0539
ISSN:
1477-0520
Pubs id:
pubs:863171
URN:
uri:b52db86c-fe64-42c8-a1f8-c34158f05fda
UUID:
uuid:b52db86c-fe64-42c8-a1f8-c34158f05fda
Local pid:
pubs:863171
Language:
English

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