Journal article
The structure of CrgA from Neisseria meningitidis reveals a new octameric assembly state for LysR transcriptional regulators
- Abstract:
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LysR-type transcriptional regulators (LTTRs) form the largest family of bacteria regulators acting as both auto-repressors and activators of target promotors, controlling operons involved in a wide variety of cellular processes. The LTTR, CrgA, from the human pathogen Neisseria meningitidis, is unregulated during bacterial-host cell contact. Here, we report the crystal structures of both regulatory domain and full-length CrgA, the first of a novel subclass of LTTRs that form ...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 2.2MB, Terms of use)
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(Preview, Version of record, pdf, 26.1MB, Terms of use)
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- Publisher copy:
- 10.1093/nar/gkp445
Authors
Funding
+ Engineering and Physical Sciences Research Council
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Funding agency for:
Lane, L
Bibliographic Details
- Publisher:
- Oxford University Press
- Journal:
- Nucleic Acids Research More from this journal
- Volume:
- 37
- Issue:
- 14
- Pages:
- 4545-4558
- Publication date:
- 2009-08-01
- DOI:
- EISSN:
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1362-4962
- ISSN:
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0305-1048
Item Description
- Language:
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English
- Subjects:
- UUID:
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uuid:b50f391d-d916-494f-9500-a5d5c7846985
- Local pid:
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ora:3025
- Deposit date:
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2009-11-05
Terms of use
- Copyright holder:
- S Sainsbury et al
- Copyright date:
- 2009
- Notes:
- Citation: Sainsbury, S. et al. (2009). 'The structure of CrgA from Neisseria meningitidis reveals a new octameric assembly state for Lys R transcriptional regulators', Nucleic Acids Research, 37(14), 4545-4558. [Available at http://nar.oxfordjournals.org/]. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
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