The intergenerational multiple deficit model and the case of dyslexia

Journal article

Which children go on to develop dyslexia? Since dyslexia has a multifactorial etiology, this question can be restated as: what are the factors that put children at high risk for developing dyslexia? It is argued that a useful theoretical framework to address this question is Pennington’s (2006) multiple deficit model (MDM). This model replaces models that attribute dyslexia to a single underlying cause. Subsequently, the generalist genes hypothesis for learning (dis)abilities (Plomin and Kovas, 2005) is described and integrated with the MDM. Next, findings are presented from a longitudinal study with children at family risk for dyslexia. Such studies can contribute to testing and specifying the MDM. In this study, risk factors at both the child and family level were investigated. This led to the proposed intergenerational MDM, in which both parents confer liability via intertwined genetic and environmental pathways. Future scientific directions are discussed to investigate parent-offspring resemblance and transmission patterns, which will shed new light on disorder etiology. http://journal.frontiersin.org/Journal/10.3389/fnhum.2014.00346/full

Authors: van Bergen, E; van der Leij, A; de Jong, P

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: Frontiers Research Foundation
• Journal: Frontiers in Human Neuroscience
• Volume: 8
• Issue: JUNE
• Article number: 346
• Publication date: 2014-06-02
• DOI: 10.3389/fnhum.2014.00346
• EISSN: 1662-5161
• Language: English
• Keywords: intergenerational transmission; intergenerational multiple deficit model; family risk; dyslexia; developmental disorders; generalist genes hypothesis; comorbidity
• Subjects: Literacy; Neurogenetics; Neurology