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An inhibitor of complement C5 provides structural insights into activation

Abstract:

The complement system is a crucial part of innate immune defenses against invading pathogens. The blood-meal of the tick Rhipicephalus pulchellus lasts for days, and the tick must therefore rely on inhibitors to counter complement activation. We have identified a class of inhibitors from tick saliva, the CirpT family, and generated detailed structural data revealing their mechanism of action. We show direct binding of a CirpT to complement C5 and have determined the structure of the C5-CirpT ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1073/pnas.1909973116

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ORCID:
0000-0001-5345-5103
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pathology Dunn School
ORCID:
0000-0002-7877-3543
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Publisher:
National Academy of Sciences Publisher's website
Journal:
Proceedings of the National Academy of Sciences Journal website
Volume:
117
Issue:
1
Pages:
362-370
Publication date:
2019-12-23
Acceptance date:
2019-11-12
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
Pubs id:
pubs:1079687
URN:
uri:b4d34415-f847-462e-8c8f-2bb5a62b4b6a
UUID:
uuid:b4d34415-f847-462e-8c8f-2bb5a62b4b6a
Local pid:
pubs:1079687
Language:
English
Keywords:

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