- Abstract:
-
The complement system is a crucial part of innate immune defenses against invading pathogens. The blood-meal of the tick Rhipicephalus pulchellus lasts for days, and the tick must therefore rely on inhibitors to counter complement activation. We have identified a class of inhibitors from tick saliva, the CirpT family, and generated detailed structural data revealing their mechanism of action. We show direct binding of a CirpT to complement C5 and have determined the structure of the C5-CirpT ...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Accepted Manuscript
- Files:
-
-
(pdf, 1.1mb)
-
- Publisher copy:
- 10.1073/pnas.1909973116
-
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- Publisher:
- National Academy of Sciences Publisher's website
- Journal:
- Proceedings of the National Academy of Sciences Journal website
- Volume:
- 117
- Issue:
- 1
- Pages:
- 362-370
- Publication date:
- 2019-12-23
- Acceptance date:
- 2019-11-12
- DOI:
- EISSN:
-
1091-6490
- ISSN:
-
0027-8424
- Pubs id:
-
pubs:1079687
- URN:
-
uri:b4d34415-f847-462e-8c8f-2bb5a62b4b6a
- UUID:
-
uuid:b4d34415-f847-462e-8c8f-2bb5a62b4b6a
- Local pid:
- pubs:1079687
- Language:
- English
- Keywords:
- Copyright date:
- 2019
- Notes:
- This is an author version of the article. The final version is available online from the publisher’s website.
Journal article
An inhibitor of complement C5 provides structural insights into activation
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