Journal article icon

Journal article

Malaria is not responsible for the selection of TCR beta-subunit variable gene haplotypes in The Gambia.

Abstract:

Previous work has shown that a single haplotype of the T-cell antigen receptor beta-subunit (TCRB) locus is predominant in African populations. This is likely to be due to selection pressure for gene(s) that protect children against disease. This study has tested the hypothesis that malaria is the responsible selection pressure, due to its impact on child mortality. The haplotypes of BV8S3, BV2S1, BV15S1, and BV3S1 were determined in children suffering from severe malaria and unaffected adult...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1007/s00251-001-0407-7

Authors


Donaldson, IJ More by this author
Boylston, AW More by this author
Journal:
Immunogenetics
Volume:
53
Issue:
10-11
Pages:
894-899
Publication date:
2002-02-05
DOI:
EISSN:
1432-1211
ISSN:
0093-7711
URN:
uuid:b4cf7348-46e5-4030-a729-d88fcc072649
Source identifiers:
53873
Local pid:
pubs:53873

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP