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Abnormal bundling and accumulation of F-actin mediates tau-induced neuronal degeneration in vivo.

Abstract:

Hyperphosphorylated forms of the microtubule-associated protein (MAP) tau accumulate in Alzheimer's disease and related tauopathies and are thought to have an important role in neurodegeneration. However, the mechanisms through which phosphorylated tau induces neurodegeneration have remained elusive. Here, we show that tau-induced neurodegeneration is associated with accumulation of filamentous actin (F-actin) and the formation of actin-rich rods in Drosophila and mouse models of tauopathy. I...

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Publisher copy:
10.1038/ncb1528

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Molecular Medicine
Elson-Schwab, I More by this author
Khurana, V More by this author
Steinhilb, ML More by this author
Spires, TL More by this author
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Journal:
Nature cell biology
Volume:
9
Issue:
2
Pages:
139-148
Publication date:
2007-02-05
DOI:
EISSN:
1476-4679
ISSN:
1465-7392
URN:
uuid:b4b925ed-1910-428c-8a54-42ebf66b678b
Source identifiers:
263888
Local pid:
pubs:263888

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