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Placental syncytiotrophoblast-derived extracellular vesicles carry active NEP (neprilysin) and are increased in preeclampsia

Abstract:

NEP (neprilysin) is a widely expressed membrane-bound metalloprotease, which binds and cleaves a variety of peptides including vasodilators, natriuretics, and diuretics. Higher levels of NEP result in hypertension—a cardinal feature of the placental disease preeclampsia. Syncytiotrophoblast-derived extracellular vesicles (EVs), comprising microvesicles and exosomes, are released into the peripheral circulation in pregnancy and are postulated as a key mechanism coupling placental dysfunction a...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
Medical Sciences
Department:
Women's and Reproductive Health
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences
Department:
Women's and Reproductive Health
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences
Department:
Women's and Reproductive Health
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences
Department:
Women's and Reproductive Health
Role:
Author
Expand authors...
Publisher:
American Heart Association Publisher's website
Journal:
Hypertension Journal website
Volume:
73
Issue:
5
Pages:
1112-1119
Publication date:
2019-04-01
Acceptance date:
2019-03-07
DOI:
EISSN:
1524-4563
ISSN:
0194-911X
Pubs id:
pubs:995349
URN:
uri:b49776ca-fffc-448a-b712-ed02c84c7e7c
UUID:
uuid:b49776ca-fffc-448a-b712-ed02c84c7e7c
Local pid:
pubs:995349

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