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Journal article

TGFβ counteracts LYVE-1-mediated induction of lymphangiogenesis by small hyaluronan oligosaccharides

Abstract:

During tissue injury, inflammation, and tumor growth, enhanced production and degradation of the extracellular matrix glycosaminoglycan hyaluronan (HA) can lead to the accumulation of small HA (sHA) oligosaccharides. We have previously reported that accumulation of sHA in colorectal tumors correlates with lymphatic invasion and lymph node metastasis, and therefore, investigated here are the effects of sHA on the lymphatic endothelium. Using cultured primary lymphatic endothelial cells (LECs) ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1007/s00109-017-1615-4

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Publisher:
Springer Verlag Publisher's website
Journal:
Journal of Molecular Medicine Journal website
Volume:
96
Issue:
2
Pages:
199-209
Publication date:
2017-12-27
Acceptance date:
2017-12-18
DOI:
EISSN:
1432-1440
ISSN:
0946-2716
Pubs id:
pubs:813637
URN:
uri:b47659f1-0bb9-49a2-9323-c26ac9ded3fb
UUID:
uuid:b47659f1-0bb9-49a2-9323-c26ac9ded3fb
Local pid:
pubs:813637

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