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Journal article

A serine/threonine kinase gene defective in Peutz-Jeghers syndrome.

Abstract:

Studies of hereditary cancer syndromes have contributed greatly to our understanding of molecular events involved in tumorigenesis. Here we investigate the molecular background of the Peutz-Jeghers syndrome (PJS), a rare hereditary disease in which there is predisposition to benign and malignant tumours of many organ systems. A locus for this condition was recently assigned to chromosome 19p. We have identified truncating germline mutations in a gene residing on chromosome 19p in multiple ind...

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Publication status:
Published

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Publisher copy:
10.1038/34432

Authors


Hemminki, A More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, WTC Human Genetics
Avizienyte, E More by this author
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Journal:
Nature
Volume:
391
Issue:
6663
Pages:
184-187
Publication date:
1998-01-05
DOI:
EISSN:
1476-4687
ISSN:
0028-0836
URN:
uuid:b453a5d0-e8ba-412a-ba88-e43c0455d3a8
Source identifiers:
36366
Local pid:
pubs:36366

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