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Journal article

Control of NFAT isoform activation and NFAT-dependent gene expression through two coincident and spatially segregated intracellular Ca(2+) signals

Abstract:

Excitation-transcription coupling, linking stimulation at the cell surface to changes in nuclear gene expression, is conserved throughout eukaryotes. How closely related coexpressed transcription factors are differentially activated remains unclear. Here, we show that two Ca(2+)-dependent transcription factor isoforms, NFAT1 and NFAT4, require distinct sub-cellular InsP3 and Ca(2+) signals for physiologically sustained activation. NFAT1 is stimulated by sub-plasmalemmal Ca(2+) microdomains, w...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.molcel.2016.11.011

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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
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Institution:
University of Oxford
Division:
MPLS
Department:
Computer Science
Role:
Author
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Institution:
University of Oxford
Oxford college:
St Anne's College
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
More from this funder
Funding agency for:
Mirams, G
Grant:
Sir Henry Dale Fellowship 101222/Z/13/Z
More from this funder
Funding agency for:
Parekh, A
Grant:
LO1047X
More from this funder
Funding agency for:
Mirams, G
Grant:
Sir Henry Dale Fellowship 101222/Z/13/Z
Publisher:
Cell Press Publisher's website
Journal:
Molecular Cell Journal website
Volume:
64
Issue:
4
Pages:
746-759
Publication date:
2016-11-17
Acceptance date:
2016-11-03
DOI:
EISSN:
1097-4164
ISSN:
1097-2765
Source identifiers:
663837
Language:
English
Keywords:
Pubs id:
pubs:663837
UUID:
uuid:b405368f-ef00-466d-b9ce-f4c6ebb5b84f
Local pid:
pubs:663837
Deposit date:
2017-05-05

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