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Control of NFAT isoform activation and NFAT-dependent gene expression through two coincident and spatially segregated intracellular Ca(2+) signals

Abstract:

Excitation-transcription coupling, linking stimulation at the cell surface to changes in nuclear gene expression, is conserved throughout eukaryotes. How closely related coexpressed transcription factors are differentially activated remains unclear. Here, we show that two Ca(2+)-dependent transcription factor isoforms, NFAT1 and NFAT4, require distinct sub-cellular InsP3 and Ca(2+) signals for physiologically sustained activation. NFAT1 is stimulated by sub-plasmalemmal Ca(2+) microdomains, w...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/j.molcel.2016.11.011

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Department:
Oxford, MSD, Physiology Anatomy and Genetics
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Author
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Department:
Oxford, MPLS, Computer Science
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Author
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Department:
St Annes College
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Author
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Department:
Oxford, MSD, Physiology Anatomy and Genetics
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Author
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Funding agency for:
Mirams, GR
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Funding agency for:
Mirams, GR
Publisher:
Cell Press Publisher's website
Journal:
Molecular Cell Journal website
Volume:
64
Issue:
4
Pages:
746-759
Publication date:
2016-11-17
Acceptance date:
2016-11-03
DOI:
EISSN:
1097-4164
ISSN:
1097-2765
Pubs id:
pubs:663837
URN:
uri:b405368f-ef00-466d-b9ce-f4c6ebb5b84f
UUID:
uuid:b405368f-ef00-466d-b9ce-f4c6ebb5b84f
Local pid:
pubs:663837
Paper number:
4
Language:
English
Keywords:

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