Journal article
Control of NFAT isoform activation and NFAT-dependent gene expression through two coincident and spatially segregated intracellular Ca(2+) signals
- Abstract:
-
Excitation-transcription coupling, linking stimulation at the cell surface to changes in nuclear gene expression, is conserved throughout eukaryotes. How closely related coexpressed transcription factors are differentially activated remains unclear. Here, we show that two Ca(2+)-dependent transcription factor isoforms, NFAT1 and NFAT4, require distinct sub-cellular InsP3 and Ca(2+) signals for physiologically sustained activation. NFAT1 is stimulated by sub-plasmalemmal Ca(2+) microdomains, w...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Authors
Funding
+ Wellcome Trust
More from this funder
Funding agency for:
Mirams, G
Grant:
Sir Henry Dale Fellowship 101222/Z/13/Z
+ Royal Society
More from this funder
Funding agency for:
Mirams, G
Grant:
Sir Henry Dale Fellowship 101222/Z/13/Z
Bibliographic Details
- Publisher:
- Cell Press Publisher's website
- Journal:
- Molecular Cell Journal website
- Volume:
- 64
- Issue:
- 4
- Pages:
- 746-759
- Publication date:
- 2016-11-17
- Acceptance date:
- 2016-11-03
- DOI:
- EISSN:
-
1097-4164
- ISSN:
-
1097-2765
- Source identifiers:
-
663837
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:663837
- UUID:
-
uuid:b405368f-ef00-466d-b9ce-f4c6ebb5b84f
- Local pid:
- pubs:663837
- Deposit date:
- 2017-05-05
Terms of use
- Copyright holder:
- Kar et al
- Copyright date:
- 2016
- Notes:
-
Copyright © 2016 The Authors. Published by Elsevier Inc.
This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
- Licence:
- CC Attribution (CC BY)
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