Journal article
Control of NFAT isoform activation and NFAT-dependent gene expression through two coincident and spatially segregated intracellular Ca(2+) signals
- Abstract:
-
Excitation-transcription coupling, linking stimulation at the cell surface to changes in nuclear gene expression, is conserved throughout eukaryotes. How closely related coexpressed transcription factors are differentially activated remains unclear. Here, we show that two Ca(2+)-dependent transcription factor isoforms, NFAT1 and NFAT4, require distinct sub-cellular InsP3 and Ca(2+) signals for physiologically sustained activation. NFAT1 is stimulated by sub-plasmalemmal Ca(2+) microdomains, w...
Expand abstract
- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Access Document
- Files:
-
-
(Version of record, pdf, 4.2MB)
-
- Publisher copy:
- 10.1016/j.molcel.2016.11.011
Why is the content I wish to access not available via ORA?
Bibliographic data (the information relating to research outputs) and full-text items (e.g. articles, theses, reports, etc.) arrive in ORA from several different sources. Unfortunately we are not able to make available the full-text for every research output.
Please contact the ORA team (
) if you have queries regarding unavailable content OR if you are aware of a full-text copy we can make available.
) if you have queries regarding unavailable content OR if you are aware of a full-text copy we can make available.
Content may be unavailable for the following four reasons
-
Version unsuitable
-
We have not obtained a suitable full-text for a given research output. See this page for more information.
-
Recently completed
-
Sometimes content is held in ORA but is unavailable for a fixed period of time to comply with the policies and wishes of rights holders.
-
Permissions
-
All content made available in ORA should comply with relevant rights, such as copyright. See this page for more information.
-
Clearance
-
Some thesis volumes scanned as part of the digitisation scheme funded by Dr Leonard Polonsky are currently unavailable due to sensitive material or uncleared third-party copyright content. We are attempting to contact authors whose theses are affected.
Alternative access to the full-text
You may be able to access the full-text directly from the publisher's website using the 'Publisher Copy' link in the 'Links & Downloads' box from a research output's ORA record page. This method may require an institutional or individual subscription to the journal/resource.
Authors
Funding
+ Wellcome Trust
More from this funder
Funding agency for:
Mirams, G
Grant:
Sir Henry Dale Fellowship 101222/Z/13/Z
+ Royal Society
More from this funder
Funding agency for:
Mirams, G
Grant:
Sir Henry Dale Fellowship 101222/Z/13/Z
Bibliographic Details
- Publisher:
- Cell Press Publisher's website
- Journal:
- Molecular Cell Journal website
- Volume:
- 64
- Issue:
- 4
- Pages:
- 746-759
- Publication date:
- 2016-11-17
- Acceptance date:
- 2016-11-03
- DOI:
- EISSN:
-
1097-4164
- ISSN:
-
1097-2765
- Source identifiers:
-
663837
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:663837
- UUID:
-
uuid:b405368f-ef00-466d-b9ce-f4c6ebb5b84f
- Local pid:
- pubs:663837
- Deposit date:
- 2017-05-05
Terms of use
- Copyright holder:
- Kar et al
- Copyright date:
- 2016
- Notes:
-
Copyright © 2016 The Authors. Published by Elsevier Inc.
This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
- Licence:
- CC Attribution (CC BY)
If you are the owner of this record, you can report an update to it here: Report update to this record