- Abstract:
-
Limitations on the number of unique protein and DNA molecules that can be characterized microscopically in a single tissue specimen impede advances in understanding the biological basis of health and disease. Here we present a multiplexed fluorescence microscopy method (MxIF) for quantitative, single-cell, and subcellular characterization of multiple analytes in formalin-fixed paraffin-embedded tissue. Chemical inactivation of fluorescent dyes after each image acquisition round allows reuse o...
Expand abstract - Publisher copy:
- 10.1073/pnas.1300136110
-
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- Journal:
- Proceedings of the National Academy of Sciences of the United States of America
- Volume:
- 110
- Issue:
- 29
- Pages:
- 11982-11987
- Publication date:
- 2013-07-05
- DOI:
- EISSN:
-
1091-6490
- ISSN:
-
0027-8424
- URN:
-
uuid:b3f560ca-8bbf-4e01-95d1-77e75f4c9e7f
- Source identifiers:
-
426712
- Local pid:
- pubs:426712
- Language:
- English
- Keywords:
- Copyright date:
- 2013
Journal article
Highly multiplexed single-cell analysis of formalin-fixed, paraffin-embedded cancer tissue.
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