Journal article
Optimization of 4D combined angiography and perfusion using radial imaging and arterial spin labeling
- Abstract:
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Purpose
To extend and optimize a non-contrast MRI technique to obtain whole head 4D (time-resolved 3D) qualitative angiographic and perfusion images from a single scan.Methods
4D combined angiography and perfusion using radial imaging and arterial spin labeling (CAPRIA) uses pseudocontinuous labeling with a 3D golden ratio (“koosh ball”) readout to continuously image the blood water as it travels through the arterial system and exchanges into the tissue. High spatial/temporal resolution angiograms and low spatial/temporal resolution perfusion images can be flexibly reconstructed from the same raw k-space data. Constant and variable flip angle (CFA and VFA, respectively) excitation schedules were optimized through simulations and tested in healthy volunteers. A conventional sensitivity encoding (SENSE) reconstruction was compared against a locally low rank (LLR) reconstruction, which leverages spatiotemporal correlations. Comparison was also made with time-matched time-of-flight angiography and multi-delay EPI perfusion images. Differences in image quality were assessed through split-scan repeatability.Results
The optimized VFA schedule (2–9°) resulted in a significant (p < 0.001) improvement in image quality (up to 84% vs. CFA), particularly for the lower SNR perfusion images. The LLR reconstruction provided effective denoising without biasing the signal timecourses, significantly improving angiographic and perfusion image quality and repeatability (up to 143%, p < 0.001). 4D CAPRIA performed well compared with time-of-flight angiography and had better perfusion signal repeatability than the EPI-based approach (p < 0.001).Conclusion
4D CAPRIA optimized using a VFA schedule and LLR reconstruction can yield high quality whole head 4D angiograms and perfusion images from a single scan.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Preview, Version of record, pdf, 5.3MB, Terms of use)
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- Publisher copy:
- 10.1002/mrm.29558
Authors
- Publisher:
- Wiley
- Journal:
- Magnetic Resonance in Medicine More from this journal
- Volume:
- 89
- Issue:
- 5
- Pages:
- 1853-1870
- Publication date:
- 2022-12-19
- Acceptance date:
- 2022-11-28
- DOI:
- EISSN:
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1522-2594
- ISSN:
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0740-3194
- Language:
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English
- Keywords:
- Pubs id:
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1311039
- Local pid:
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pubs:1311039
- Deposit date:
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2022-12-02
Terms of use
- Copyright holder:
- Okell and Chiew
- Copyright date:
- 2022
- Rights statement:
- © 2022 The Authors. Magnetic Resonance in Medicine published by Wiley Periodicals LLC on behalf of International Society for Magnetic Resonance in Medicine. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
- Notes:
- This research was funded in whole or in part by the Wellcome Trust (220204/Z/20/Z and 203139/Z/16/Z). For the purposes of Open Access, the author has applied a CC BY public copyright licence to any Author Accepted Manuscript (AAM) version arising from this submission.
- Licence:
- CC Attribution (CC BY)
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