Journal article
Substrate specificity of rhomboid intramembrane proteases is governed by helix-breaking residues in the substrate transmembrane domain.
- Abstract:
-
Rhomboid intramembrane proteases initiate cell signaling during Drosophila development and Providencia bacterial growth by cleaving transmembrane ligand precursors. We have determined how specificity is achieved: Drosophila Rhomboid-1 is a site-specific protease that recognizes its substrate Spitz by a small region of the Spitz transmembrane domain (TMD). This substrate motif is necessary and sufficient for cleavage and is composed of residues known to disrupt helices. Rhomboids from diverse ...
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- Publication status:
- Published
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- Publisher copy:
- 10.1016/s1097-2765(03)00181-3
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Bibliographic Details
- Journal:
- Molecular cell
- Volume:
- 11
- Issue:
- 6
- Pages:
- 1425-1434
- Publication date:
- 2003-06-01
- DOI:
- EISSN:
-
1097-4164
- ISSN:
-
1097-2765
- Source identifiers:
-
356077
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:356077
- UUID:
-
uuid:b3cada42-9955-4218-8058-b233c44498b2
- Local pid:
- pubs:356077
- Deposit date:
- 2013-11-16
Terms of use
- Copyright date:
- 2003
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