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Substrate specificity of rhomboid intramembrane proteases is governed by helix-breaking residues in the substrate transmembrane domain.

Abstract:

Rhomboid intramembrane proteases initiate cell signaling during Drosophila development and Providencia bacterial growth by cleaving transmembrane ligand precursors. We have determined how specificity is achieved: Drosophila Rhomboid-1 is a site-specific protease that recognizes its substrate Spitz by a small region of the Spitz transmembrane domain (TMD). This substrate motif is necessary and sufficient for cleavage and is composed of residues known to disrupt helices. Rhomboids from diverse ...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Journal:
Molecular cell
Volume:
11
Issue:
6
Pages:
1425-1434
Publication date:
2003-06-05
DOI:
EISSN:
1097-4164
ISSN:
1097-2765
URN:
uuid:b3cada42-9955-4218-8058-b233c44498b2
Source identifiers:
356077
Local pid:
pubs:356077

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