Clinical impact and reliability of pleural fluid mesothelin in undiagnosed pleural effusions.

Journal article

RATIONALE: Serum mesothelin is a new biomarker for the diagnosis of mesothelioma. Patients with mesothelioma commonly present with pleural effusions. To define the clinical utility of mesothelin quantification in pleural fluid, we assessed its additional value over pleural fluid cytology and its short-term reproducibility and reliability after pleural inflammatory processes, including pleurodesis. OBJECTIVES: To assess the diagnostic role of pleural fluid mesothelin and the effect of common c...

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Authors: Davies, H; Sadler, R; Bielsa, S; Maskell, N; Rahman, N

• Publication status: Published
• Journal: American journal of respiratory and critical care medicine
• Volume: 180
• Issue: 5
• Pages: 437-444
• Publication date: 2009-09-01
• DOI: 10.1164/rccm.200811-1729oc
• EISSN: 1535-4970
• ISSN: 1073-449X
• Language: English
• Keywords: GPI-Linked Proteins; Female; Pleural Effusion, Malignant; Prospective Studies; Male; Pleural Effusion; Membrane Glycoproteins; Mesothelioma; Aged; Pleurodesis; Bacterial Infections; Sensitivity and Specificity; Reproducibility of Results; Humans