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Development of specific collagen scaffolds to support the osteogenic and chondrogenic differentiation of human bone marrow stromal cells.

Abstract:

Type I Collagen matrices of defined porosity, incorporating carbonate substituted hydroxyapatite (HA) crystals, were assessed for their ability to support osteo- and chondrogenic differentiation of human bone marrow stromal cells (HBMSCs). Collagen-HA composite scaffolds supported the osteogenic differentiation of HBMSCs both in vitro and in vivo as demonstrated by histological and micro-CT analyses indicating the extensive penetration of alkaline phosphatase expressing cells and new matrix s...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MPLS, Materials
Role:
Author
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Journal:
Biomaterials
Volume:
29
Issue:
21
Pages:
3105-3116
Publication date:
2008-07-05
DOI:
EISSN:
1878-5905
ISSN:
0142-9612
URN:
uuid:b33802c8-1b09-4757-8a62-c971795af220
Source identifiers:
19462
Local pid:
pubs:19462

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