Zika Virus Neuropathogenesis: The Different Brain Cells, Host Factors and Mechanisms Involved

Komarasamy, TV; Adnan, NAA; James, W; Balasubramaniam, VRMT

Neuroscience & Neuroimaging Research Collection

Journal article

Zika Virus Neuropathogenesis: The Different Brain Cells, Host Factors and Mechanisms Involved

Abstract:: Background: Zika virus, Kunjin virus, Yellow Fever virus, & Sindbis virus belong to Flaviviridae family and are involved in derailing various biological pathways which are not yet elucidated. Aim: Understanding the gene as well as miRNA interplay which plays a vital role in pathogenesis in the diagnosis and prognosis of the disease is of utmost significance. Materials and Methods: By leveraging microarray data from the Gene Expression Omnibus GSE232504 dataset, we meticulously examined the differentially expressed genes & micro RNAs (miRNAs) induced by viral infections. Results: Our analysis revealed 60 statistically significant and differentially expressed genes (DEGs) out of a total of 18,725, with SESN2 (SESTRIN 2) and GADD45A (Growth Arrest and DNA Damage-Inducible Alpha) standing out as highly significant players in the host cell response to these viruses. hsa-miR-148b-3p, hsa-miR-148a-3p, hsa-miR-607 & hsa-miR-5582-3p were the highly expressed micro RNAs (miRNAs). Through functional enrichment analyses, we unveiled significant pathways, including Type 1 Diabetes Mellitus and NF-kappa B Signaling, shedding light on the potential mechanisms underlying these virus-host cell interactions. Furthermore, our PPI (protein-protein interaction) network analysis highlighted key hub genes, while our exploration of miRNA-gene targeting relationships offered valuable insights into post-transcriptional regulation. Conclusion: This study provides a robust foundation for understanding the molecular intricacies of virus-host cell interactions, offering potential targets for further experimental validation and paving the way for innovative therapeutic approaches in combatting viral infections and associated diseases

Publication status:: Published

Peer review status:: Peer reviewed

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APA Style

Komarasamy, T. V., Adnan, N. A. A., James, W., & Balasubramaniam, V. R. M. T. (2022). Zika Virus Neuropathogenesis: The Different Brain Cells, Host Factors and Mechanisms Involved. Frontiers in Immunology, 13, 773191–773191.

MLA Style

Komarasamy, TV, et al. “Zika Virus Neuropathogenesis: The Different Brain Cells, Host Factors and Mechanisms Involved.” Frontiers in Immunology, vol. 13, 2022, pp. 773191–91.

Chicago Style

Komarasamy, TV, NAA Adnan, W James, and VRMT Balasubramaniam. 2022. “Zika Virus Neuropathogenesis: The Different Brain Cells, Host Factors and Mechanisms Involved.” Frontiers in Immunology 13: 773191–91.
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