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The effect of dose on the antimalarial efficacy of artemether-lumefantrine: a systematic review and pooled analysis of individual patient data

Abstract:

Background: Artemether-lumefantrine is the most widely used artemisinin-based combination therapy for malaria, although treatment failures occur in some regions. We investigated the effect of dosing strategy on efficacy in a pooled analysis from trials done in a wide range of malaria-endemic settings. Methods: We searched PubMed for clinical trials that enrolled and treated patients with artemether-lumefantrine and were published from 1960 to December, 2012. We merged individual patient data ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Department:
Oxford, MSD, NDM, Tropical Medicine
Role:
Author
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Bill and Melinda Gates Foundation More from this funder
Publisher:
Elsevier Publisher's website
Journal:
Lancet Infectious Diseases Journal website
Volume:
15
Issue:
6
Pages:
692-702
Publication date:
2015-06-05
DOI:
EISSN:
1474-4457
ISSN:
1473-3099
URN:
uuid:b2eccdf4-1ff8-493b-a182-41e6e36cb478
Source identifiers:
516085
Local pid:
pubs:516085

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