Journal article
The South Asian genome
- Abstract:
- The genetic sequence variation of people from the Indian subcontinent who comprise one-quarter of the world's population, is not well described. We carried out whole genome sequencing of 168 South Asians, along with whole-exome sequencing of 147 South Asians to provide deeper characterisation of coding regions. We identify 12,962,155 autosomal sequence variants, including 2,946,861 new SNPs and 312,738 novel indels. This catalogue of SNPs and indels amongst South Asians provides the first comprehensive map of genetic variation in this major human population, and reveals evidence for selective pressures on genes involved in skin biology, metabolism, infection and immunity. Our results will accelerate the search for the genetic variants underlying susceptibility to disorders such as type-2 diabetes and cardiovascular disease which are highly prevalent amongst South Asians.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Access Document
- Files:
-
-
(Preview, Version of record, pdf, 1.1MB, Terms of use)
-
- Publisher copy:
- 10.1371/journal.pone.0102645
Authors
- Publisher:
- Public Library of Science
- Journal:
- PLoS ONE More from this journal
- Volume:
- 9
- Issue:
- 8
- Pages:
- e102645
- Publication date:
- 2014-08-12
- Acceptance date:
- 2014-06-21
- DOI:
- EISSN:
-
1932-6203
- Language:
-
English
- Keywords:
- UUID:
-
uuid:b2e39e5b-d0c1-41dd-a87d-ee365e0c583f
- Local pid:
-
pubs:480025
- Source identifiers:
-
480025
- Deposit date:
-
2014-08-21
Terms of use
- Copyright holder:
- Chambers et al
- Copyright date:
- 2014
- Notes:
- © 2014 Chambers et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
- Licence:
- CC Attribution (CC BY)
If you are the owner of this record, you can report an update to it here: Report update to this record