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An antivector vaccine protects against a lethal vector-borne pathogen.

Abstract:

Vaccines that target blood-feeding disease vectors, such as mosquitoes and ticks, have the potential to protect against the many diseases caused by vector-borne pathogens. We tested the ability of an anti-tick vaccine derived from a tick cement protein (64TRP) of Rhipicephalus appendiculatus to protect mice against tick-borne encephalitis virus (TBEV) transmitted by infected Ixodes ricinus ticks. The vaccine has a "dual action" in immunized animals: when infested with ticks, the inflammatory ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.ppat.0020027

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Institution:
University of Oxford
Role:
Author
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Institution:
University of Oxford
Role:
Author
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Grant:
APVT-51–004702
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS pathogens Journal website
Volume:
2
Issue:
4
Pages:
e27
Publication date:
2006-04-05
DOI:
EISSN:
1553-7374
ISSN:
1553-7366
URN:
uuid:b2b75506-e095-4528-8d76-41bc82919c1d
Source identifiers:
404195
Local pid:
pubs:404195

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