Journal article
Alpha-synuclein oligomers: a new hope.
- Abstract:
- Alpha-synuclein is a protein implicated in Parkinson's disease and thought to be one of the main pathological drivers in the disease, although it remains unclear how this protein elicits its neurotoxic effects. Recent findings indicate that the assembly of toxic oligomeric species of alpha-synuclein may be one of the key processes for the pathology and spread of the disease. The absence of a sensitive in situ detection method has hindered the study of these oligomeric species and the role they play in the human brain until recently. In this review, we assess the evidence for the toxicity and prion-like activity of oligomeric forms of alpha-synuclein and discuss the advances in our understanding of the role of alpha-synuclein in Parkinson's disease that may be brought about by the specific and sensitive detection of distinct oligomeric species in post-mortem patient brain. Finally, we discuss current approaches being taken to therapeutically target alpha-synuclein oligomers and their implications.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 4.8MB, Terms of use)
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- Publisher copy:
- 10.1007/s00401-017-1755-1
Authors
- Publisher:
- Springer
- Journal:
- Acta Neuropathologica More from this journal
- Publication date:
- 2017-07-01
- Acceptance date:
- 2017-07-22
- DOI:
- EISSN:
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1432-0533
- ISSN:
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0001-6322
- Pmid:
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28803412
- Language:
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English
- Keywords:
- Pubs id:
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pubs:724113
- UUID:
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uuid:b2b35738-d309-4286-8635-fa80ebc6a4b5
- Local pid:
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pubs:724113
- Source identifiers:
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724113
- Deposit date:
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2017-09-28
Terms of use
- Copyright holder:
- *Copyright holder name ("et al" as required)*
- Copyright date:
- 2017
- Notes:
- © The Author(s) 2017. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
- Licence:
- CC Attribution (CC BY)
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