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Journal article

Whole-exome sequencing of 228 patients with sporadic Parkinson's disease.

Abstract:

Parkinson’s disease (PD) is the most common neurodegenerative movement disorder, affecting 1% of the population over 65 years characterized clinically by both motor and non-motor symptoms accompanied by the preferential loss of dopamine neurons in the substantia nigra pars compacta. Here, we sequenced the exomes of 244 Parkinson’s patients selected from the Oxford Parkinson’s Disease Centre Discovery Cohort and, after quality control, 228 exomes were available for analyses. The PD patient exo...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1038/srep41188

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Department:
Oxford, MSD, Physiology Anatomy and Genetics
Role:
Author
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Department:
Oxford, MSD, Clinical Neurosciences
Role:
Author
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National Institute for Health Research More from this funder
Dementias and Neurodegenerative Diseases Research Network More from this funder
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Grant:
Monument Trust Discovery Award
Publisher:
Nature Publishing Group Publisher's website
Journal:
Scientific Reports Journal website
Volume:
7
Pages:
41188
Publication date:
2017-01-05
Acceptance date:
2016-12-16
DOI:
ISSN:
2045-2322
Pubs id:
pubs:673199
URN:
uri:b2a5a2d5-ef02-4b2f-8d38-1d3106987e61
UUID:
uuid:b2a5a2d5-ef02-4b2f-8d38-1d3106987e61
Local pid:
pubs:673199
Language:
English
Keywords:

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