Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution.

Journal article

To identify genetic loci influencing central obesity and fat distribution, we performed a meta-analysis of 16 genome-wide association studies (GWAS, N = 38,580) informative for adult waist circumference (WC) and waist-hip ratio (WHR). We selected 26 SNPs for follow-up, for which the evidence of association with measures of central adiposity (WC and/or WHR) was strong and disproportionate to that for overall adiposity or height. Follow-up studies in a maximum of 70,689 individuals identified two loci strongly associated with measures of central adiposity; these map near TFAP2B (WC, P = 1.9x10(-11)) and MSRA (WC, P = 8.9x10(-9)). A third locus, near LYPLAL1, was associated with WHR in women only (P = 2.6x10(-8)). The variants near TFAP2B appear to influence central adiposity through an effect on overall obesity/fat-mass, whereas LYPLAL1 displays a strong female-only association with fat distribution. By focusing on anthropometric measures of central obesity and fat distribution, we have identified three loci implicated in the regulation of human adiposity.

Authors: Lindgren, C; Heid, I; Randall, J; Lamina, C; Steinthorsdottir, V

• Publication status: Published
• Journal: PLoS genetics
• Volume: 5
• Issue: 6
• Pages: e1000508
• Publication date: 2009-06-01
• DOI: 10.1371/journal.pgen.1000508
• EISSN: 1553-7404
• ISSN: 1553-7390
• Language: English
• Keywords: Waist-Hip Ratio; Transcription Factor AP-2; Obesity; Oxidoreductases; Adult; Procardis Consortia; Genome-Wide Association Study; Wellcome Trust Case Control Consortium; Body Fat Distribution; Waist Circumference; Humans; Female; Methionine Sulfoxide Reductases; Giant Consortium; Lysophospholipase; Adiposity; Polymorphism, Single Nucleotide; Cohort Studies; Male