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Lack of association of DRD2 rs1800497 (Taq1A) polymorphism with smoking cessation in a nicotine replacement therapy randomized trial.

Abstract:

INTRODUCTION: We previously reported evidence that the T allele of the dopamine type-2 receptor (DRD2) rs1800497 polymorphism is associated with improved response to nicotine replacement therapy (NRT) relative to placebo and that this association may only be present in females. However, evidence of the poor replication validity of genetic association studies is growing, particularly among those that report subgroup analyses. We therefore attempted to replicate our previous finding of an asso...

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Publication status:
Published

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Publisher copy:
10.1093/ntr/ntp007

Authors


Munafò, MR More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
More by this author
Institution:
University of Oxford
Department:
Oxford
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Primary Care Health Sciences
Journal:
Nicotine and tobacco research : official journal of the Society for Research on Nicotine and Tobacco
Volume:
11
Issue:
4
Pages:
404-407
Publication date:
2009-04-05
DOI:
EISSN:
1469-994X
ISSN:
1462-2203
URN:
uuid:b2820408-8765-4695-aefe-f38c9756f4e1
Source identifiers:
191234
Local pid:
pubs:191234

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